Irreversible Electroporation Systems for Clinical Use

摘要: Electroporation is a technique that uses micro to milliseconds electric pulses create pores in the cell membrane, thus allowing molecules that, due their physical and/or chemical properties, would normally not be able cross enter (1-5). finds applications many fields particular for gene insertion cells (electrogenetherapy) (6,7) and treatment of cancer (electrochemotherapy). In electrochemotherapy, combination chemotherapy electroporation tumour cells, effects drugs usually show little cytotoxicity are greatly increased (8). The opening membrane allows chemotherapeutic agent at greater, more effective concentration exert its cytotoxic action by killing target (9-11).