Systemic Contact Dermatitis

摘要: Systemic contact dermatitis (SCD) traditionally refers to a skin condition where an individual who is cutaneously sensitized allergen will subsequently react that same or cross reacting via different route. It occurs allergens including metals, medications, and foods. The exact pathophysiology underlying this disease remains unknown, although it appears be mediated by type 4 hypersensitivity reactions possibly 3 reactions. p-I concept (pharmacologic interaction with immunoreceptors) hypothesized drugs are able bind directly T cell receptor without first being presented MHC (major histocompatibility complex) molecules prior metabolism, which would help explain why SCD can seen on exposure medications. Nomenclature challenge as subcategorized using terms such ACDS (allergic syndrome) its four clinical stages, Baboon syndrome, SDRIFE (symmetrical drug-related intertriginous flexural exanthema), share many overlapping features. Food may responsible for uncontrolled persistent symptoms in patients do not respond topical avoidance. With induced application versus systemic administration. Patch testing (PT) beneficial diagnosing caused metals medications corticosteroids, antimicrobials (ampicillin, bacitracin, erythromycin, neomycin, nystatin), NSAIDs (diclofenac, ibuprofen), anesthetics, antihistamines (chlorphenamine, piperazine). Current treatment options include steroids oral symptom relief dietary avoidance causative foods metals.