Anxiety Disorders are Associated with Reduced Heart Rate Variability: A Meta-Analysis
作者： John A. Chalmers , Daniel S. Quintana , Maree J.-Anne Abbott , Andrew H. Kemp
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摘要: Background: Anxiety disorders increase risk of future cardiovascular disease (CVD) and mortality, even after controlling for confounds including smoking, lifestyle, socioeconomic status, irrespective a history medical disorders. While impaired vagal function, indicated by reductions in heart rate variability (HRV), may be one mechanism linking anxiety to CVD, prior studies have reported inconsistent findings highlighting the need meta-analysis. Method: Studies comparing resting state HRV recordings patients with an disorder as primary diagnosis healthy controls were considered Results: Meta-analyses based on 36 articles, 2086 2294 controls. Overall, characterised lower (high frequency: Hedges’ g = -.29. 95%CI: -.41 -.17, p < 0.001; time domain: -0.45, -0.57 -0.33, .001) than Panic Disorder (n=447), Post-Traumatic Stress (n=192), Generalized (n=68), Social (n=90), but not Obsessive Compulsive (n=40), displayed high frequency relative (all ps .001). Conclusions: are associated reduced HRV, small moderate effect size. Findings important implications physical health wellbeing patients, comprehensive reduction.
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