Determination of coronary flow reserve by digital angiography: Validation of a practical method not requiring power injection or electrocardiographic gating

摘要: Abstract Although coronary flow reserve is a well established measure of the physiologic significance off atherosclerotic stenosis, cumbersome methodology has prevented its widespread clinical application. This study evaluated new simplified method measuring based on indicator-dilution analysis hand-injected digital arteriograms. In five dogs, circumflex artery was instrumented with an angiographic catheter, electromagnetic probe and pneumatic occluder. For each 18 stenoses varying severity, arteriograms were obtained under basal conditions during papaverine-induced hyperemia. A pair background-corrected arterial time-density curves generated for stenosis by off-line computer Coronary calculated from measured areas known volume contrast medium used to produce curve. Angiographic ranged 0.9 6.1 (mean 2.99), whereas 0.7 6.9 3.02). measurements correlated (r = 0.86). establishes that 30 frames/s arteriography permits accurate determination reserve. The technique described employs hand injection small doses radiographic using conventional catheters, should be readily applicable human disease.