Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers.

摘要: Introduction Alcohol is among the most commonly used psychoactive drugs, yet it can produce markedly different subjective effects in people. Certain effects, including both heightened stimulatory and lesser sedative are thought to predict repeated or excessive use. However, we do not fully understand nature of these individual differences their relationships alcohol consumption. This controlled laboratory study examined physiologic responses a moderate dose social drinkers relation subjects' decision consume alcohol. Methods Healthy adult volunteers (N = 95) participated 5-session double-blind choice study. On first 4 sessions, they received (0.8 g/kg) placebo alternating order, on fifth session, chose consumed whichever 2 preferred. During each participants completed Profile Mood States (POMS) Biphasic Effects Scale (BAES) questionnaires had vitals recorded every 30 minutes. We compared response during sampling sessions who session 5. Results Of 95 participants, 55 (choosers) 40 (nonchoosers). In full sample, produced its expected (e.g., increased friendliness, elation, vigor (POMS), stimulation sedation (BAES)). The chooser nonchooser groups did differ demographic characteristics, blood levels, cardiovascular measures. choosers experienced greater alcohol-induced increases positive mood liked drug more, whereas nonchoosers anger, anxiety after Conclusion Both predicted preference under conditions, suggesting that factors future consumption