Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing: Longitudinal Cohort and Mendelian Randomization Analyses.

摘要: Dietary intakes of polyunsaturated, monounsaturated and saturated fatty acids (FAs) have been inconsistently associated with puberty timing. We examined longitudinal associations prepubertal dietary plasma phospholipid FAs several timing traits in boys girls. In the Avon Longitudinal Study Parents Children, fat at 3-7.5 years 7.5 were measured. Timings Tanner stage 2 genital or breast development voice breaking menarche from repeated reports 8-17 years, age peak height velocity (PHV) measurements 5-20 estimated. linear regression models adjustment for maternal infant characteristics, substitution polyunsaturated FAs, higher concentrations dihomo-γ-linolenic acid (20:3n6) palmitoleic (16:1n7) earlier girls (n = 3872) but not 3654). Mendelian Randomization models, genetically predicted circulating was Based on intake data, objectively measured genetic causal inference, these findings suggest that endogenous metabolic pathways increase acid, an intermediate metabolite n-6 may promote