Metabolic and Clinical Significance of the Lipoprotein Family Concept

摘要: Plasma lipoproteins represent a unique and complex system of macromolecular compounds, the principal function which is to transport lipids throughout organism deliver them various cellular sites for utilization either as fuel or structural components. Due presence protein moieties (apolipoproteins) plasma are charged macromolecules behave in electric field simple proteins. However, due lipid constituents (neutral lipids, phospholipids glycosphingolipids) possess relatively low hydrated densities gravitational more than The electrophoretic mobility density have been utilized most important operational criteria characterizing classifying lipoproteins. application zonal electrophoresis showed at least four major lipid-stained bands origin, pre-β, β- α1-positions (1). Gofman his coworkers (2) developed preparative procedure ultracentrifugal fractionation observed discontinuous distribution lipoprotein particles along gradient ranging from 0.92 1.21 g/ml.