Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation
作者： Suan-Sin Foo , Weiqiang Chen , Adam Taylor , Kuo-Ching Sheng , Xing Yu
DOI: 10.1371/JOURNAL.PPAT.1004649
关键词:
摘要: The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River (RRV), the lack antiviral treatments highlight potential threat a global pandemic. immune responses underlying virulence remain enigmatic. We found that pentraxin 3 (PTX3) was highly expressed in CHIKV RRV patients during acute disease. Overt expression PTX3 associated with increased viral load disease severity. PTX3-deficient (PTX3-/-) mice acutely infected exhibited delayed progression rapid recovery through diminished inflammatory replication. Furthermore, binding N-terminal domain to facilitated entry Thus, our study demonstrates pivotal role shaping alphavirus-triggered immunity provides new insights into pathogenesis.
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