The Influences of CD14 −260C>T Polymorphism on Survival in ICU Critically Ill Patients
作者： Paulo R. V. Fallavena , Thiago J. Borges , Diego D. Paskulin , Francis J. O. Paludo , Thayse B. Goetze
DOI: 10.3109/08820130903258818
关键词:
摘要: In order to analyze the effect of two different versions cluster differentiation 14 (CD14) receptor recognizing gene on survival, we determined −260C>T single nucleotide polymorphism (SNP) frequencies in 514 critically ill patients. We compared −260TT homozygotes with −260C allele carriers (−260CC and −260CT genotypes) demonstrated—260TT patients had highest survival rate (82% vs 64%; p T genotype groups main clinical predictors exclude other risk factors that could influence outcome from critical illness: higher age, APACHE II score, length stay at hospital, occurrence sepsis septic shock were Intensive Care Unit (ICU) patient's mortality, but was protective factor toward (p = 0.001; OR 3.08 95%CI 1.54–5.98). Among patients, also protectiv...
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W Ertel, JP Kremer, J Kenney, U Steckholzer, D Jarrar, O Trentz, FW Schildberg, Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood. ,vol. 85, pp. 1341- 1347 ,(1995) , 10.1182/BLOOD.V85.5.1341.BLOODJOURNAL8551341
J-L. Vincent, F. Lopes Ferreira, Multiple Organ Failure: Clinical Syndrome Springer Berlin Heidelberg. pp. 394- 403 ,(2002) , 10.1007/978-3-642-56107-8_28
B Farber, P Cao, J Silver, T Glück, S M Goyert, M Epstein, Parameters influencing membrane CD14 expression and soluble CD14 levels in sepsis. European Journal of Medical Research. ,vol. 6, pp. 351- 358 ,(2001)
Tricia D. LeVan, John W. Bloom, Thomas J. Bailey, Christopher L. Karp, Marilyn Halonen, Fernando D. Martinez, Donata Vercelli, A Common Single Nucleotide Polymorphism in the CD14 Promoter Decreases the Affinity of Sp Protein Binding and Enhances Transcriptional Activity The Journal of Immunology. ,vol. 167, pp. 5838- 5844 ,(2001) , 10.4049/JIMMUNOL.167.10.5838
D.E. Zhang, C.J. Hetherington, S. Tan, S.E. Dziennis, D.A. Gonzalez, H.M. Chen, D.G. Tenen, Sp1 is a critical factor for the monocytic specific expression of human CD14. Journal of Biological Chemistry. ,vol. 269, pp. 11425- 11434 ,(1994) , 10.1016/S0021-9258(19)78141-1
Roman Dziarski, Richard I. Tapping, Peter S. Tobias, Binding of bacterial peptidoglycan to CD14 Journal of Biological Chemistry. ,vol. 273, pp. 8680- 8690 ,(1998) , 10.1074/JBC.273.15.8680
Jaroslav A. Hubacek, Jan Pit’ha, Zdena Škodová, Vladimír Stanĕk, Rudolf Poledne, C(−260)→T Polymorphism in the Promoter of the CD14 Monocyte Receptor Gene as a Risk Factor for Myocardial Infarction Circulation. ,vol. 99, pp. 3218- 3220 ,(1999) , 10.1161/01.CIR.99.25.3218
Wolfgang Koenig, Natalie Khuseyinova, Michael M Hoffmann, Winfried März, Margit Fröhlich, Albrecht Hoffmeister, Hermann Brenner, Dietrich Rothenbacher, CD14 C(-260)→T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease Journal of the American College of Cardiology. ,vol. 40, pp. 34- 42 ,(2002) , 10.1016/S0735-1097(02)01937-X
Werner Koch, Adnan Kastrati, Julinda Mehilli, Nicolas von Beckerath, Albert Schömig, CD14 gene -159C/T polymorphism is not associated with coronary artery disease and myocardial infarction. American Heart Journal. ,vol. 143, pp. 971- 976 ,(2002) , 10.1067/MHJ.2002.122512
Bibiana Butkus de Aguiar, Ingrid Girardi, Diego D'Avila Paskulin, Everaldo de França, Cláudia Dornelles, Fernando Suparregui Dias, Cristina Bonorino, Clarice Sampaio Alho, CD14 expression in the first 24h of sepsis: effect of -260C>T CD14 SNP. Immunological Investigations. ,vol. 37, pp. 752- 769 ,(2008) , 10.1080/08820130802403242