Immunologic Techniques Utilized in the Diagnosis of Occupational Lung Disease

摘要: SUMMARY Numerous immunologic diagnostic modalities are available to the clinician investigating etiology of occupational lung disorders. Certain tests—immunoassays for specific anti-IgE antibody, gel diffusion reactions, and immunoelectrophoretic techniques—may aid in identification antigens or analysis involved pathogenesis environmental diseases. Other techniques—ANA assays, complement studies, immune complex assays—should be regarded as complementary. For example, a non-histone nucleoprotein “marker,” ANA has not been identified any fibrotic diseases, positivity does always correlate with severity progression disease. Additionally assays detection circulating complexes do identify antigens. Clearly, there other useful determining mechanisms that may important diseases but were discussed this article. Bronchoalveolar lavage cellular lymphocyte subtyping clinically therapeutically when considering activity various Also, lymphokine leukotriene identification, transformation assessment macrophage function contributing greatly our understanding possible different pulmonary Thus, investigation offers an exciting rewarding future evaluation pathologic