Three-dimensional organization of block copolymers on "DNA-minimal" scaffolds.
作者： Christopher K. McLaughlin , Graham D. Hamblin , Kevin D. Hänni , Justin W. Conway , Manoj K. Nayak
DOI: 10.1021/JA210313P
关键词:
摘要: Here, we introduce a 3D-DNA construction method that assembles minimum number of DNA strands in quantitative yield, to give scaffold with large single-stranded arms. This frame is used as core structure organize other functional materials 3D the shell. We use ring-opening metathesis polymerization (ROMP) generate block copolymers are covalently attached strands. Site-specific hybridization these DNA-polymer chains on arms gives efficient access DNA-block copolymer cages. These biohybrid cages possess polymer programmably positioned three dimensions and display increased nuclease resistance compared unfunctionalized
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