Molecular Determinants Controlling Functional Properties of AMPARs and NMDARs in the Mammalian CNS

摘要: L-a-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) and N-methyl-D-aspartate (NMDARs) are the two major types of postsynaptic glutamate (GluRs) that mediate excitatory synaptic transmission in mammalian central nervous system (CNS). Both AMPARs NMDARs multimeric proteins, probably tetramers, formed by a variety molecularly distinct subunits. can be assembled from four subunits, termed GIuR-A, -B, -C, -D (or, an alternative nomenclature, G1uR1, G1uR2, GluR3, G1uR4). Additional molecular diversity is generated splicing flip-flop module RNA editing at Q/R R/G site. heteromers primarily NR1 subunits NR2A, B, C, or D Various splice variants have been identified for subunit, new NR3 subunit has discovered recently. Considering all combinatorial possibilities, glutamate-receptor channels considerable (Hollmann, this volume).