Effect of a Short Course of Prednisone in the Prevention of Early Relapse after the Emergency Room Treatment of Acute Asthma
作者： Kenneth R. Chapman , P. Richard Verbeek , John G. White , Anthony S. Rebuck
DOI: 10.1056/NEJM199103213241202
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摘要: Abstract Background. Relapse after the treatment of acute asthma in emergency room is common (occurring 25 to 30 percent cases) and not accurately predicted by any available measurements. We studied usefulness prednisone reducing this high rate relapse. Methods. One hundred twenty-two patients treated for exacerbations were assigned a randomized, double-blind fashion receive at discharge either eight days (the dose being tapered from 40 0 mg per day) or matching placebo. Ninety-three subsequently discharged participated trial. On 1, 7, 14 discharge, assessed during home visits with spirometry diary-card review; they contacted telephone on day 21. was defined as an unscheduled medical visit occasioned patient's perceived need further treatment. Results. The overall risk relapse significantly lower the...
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