Selective [15Nη2] labelling of an NG-propionylated arginine derivative
作者： Roland Kleinmaier , Ruth M. Gschwind
DOI: 10.1002/JLCR.1564
关键词:
摘要: A straightforward convergent synthesis of [15N]-Bz-Arg(Nη-propionyl)-OEt*TFA is presented. In this approach, the guanidinylation reagent [15N2]-N(boc)-N′(propionyl)-S-methylisothiourea reacted with side chain amino group title compound's ornithine precursor. The step promoted by stoichiometric addition HgCl2 to force completion. This method leads directly NG-acylated product and acyl residue principally modifiable in last synthetic reagent. Copyright © 2008 John Wiley & Sons, Ltd.
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