Novel Eicosapentaenoic Acid-derived F3-isoprostanes as Biomarkers of Lipid Peroxidation
作者： Wen-Liang Song , Georgios Paschos , Susanne Fries , Muredach P. Reilly , Ying Yu
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摘要: Isoprostanes (iPs) are prostaglandin (PG) isomers generated by free radical-catalyzed peroxidation of polyunsaturated fatty acids (PUFAs). Urinary F(2)-iPs, PGF(2alpha) derived from arachidonic acid (AA) used as indices lipid in vivo. We now report the characterization two major F(3)-iPs, 5-epi-8,12-iso-iPF(3alpha)-VI and 8,12-iso-iPF(3alpha)-VI, omega-3 acid, eicosapentaenoic (EPA). Although potential therapeutic benefits EPA receive much attention, a shift toward diet rich PUFAs may also predispose to enhanced peroxidation. 8,12-iso-iPF(3alpha)-VI highly correlated unaltered cyclooxygenase inhibition humans. Fish oil dose-dependently elevates urinary F(3)-iPs mice dietary omega-3/omega-6 is reflected an increasing slope [m] line relating 8, 12-iso-iPF(3alpha)-VI 8,12-iso-iPF(2alpha)-VI. Administration bacterial lipopolysaccharide evokes reversible increase both 8,12-iso-iPF(2alpha)-VI humans on ad lib diet. However, while excretion iPs (R(2) median = 0.8), varies order magnitude, reflecting marked inter-individual variability relative versus omega-6 substrates. Clustered analysis F(2)- refines assessment oxidant stress response inflammatory stimulus vivo integrating intake PUFAs.
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