The Clinical Usefulness of Acth and Cortisone in Liver Disease

摘要: Summary It seems clear from the data presented that routine use of ACTH and cortisone is not indicated in any form liver disease. The results to date with this therapy are unpredictable. From present experience it likely and/or patients acute hepatic disease viral origin where jaundice deep sustained for several weeks. One can expect a rapid diminution serum bilirubin these patients. A trial corticosteroid probably also hepatitis who have suffered spontaneous relapse their In usual patient remains jaundiced 3 5 weeks, on other hand, will prove be useful unless further studies demonstrate significant shortening convalescent period by corticosteroids. regular return well-being appetite continued improvement function which resulted certain cases chronic would seem make substances desirable, particularly those conservative has failed. should remembered, however, sodium water retention result corticosteroids may complicate management such degree one forced withdraw medication. Similarly cirrhosis under circumstances. addition salt retention, possibility precipitating bleeding esophageal varices considered. If shown administration large amounts potassium prevent disease, additional, perhaps more vigorous, trials warranted. sudden withdrawal precipitate On caused no demonstrable harm as far itself concerned. evidence favoring coma been convincing. view otherwise poor prognosis, an adjunct measures indicated.