Hydrodynamic Models of G-Quadruplex Structures
作者： Jonathan B. Chaires , William L. Dean , Huy T. Le , John O. Trent
DOI: 10.1016/BS.MIE.2015.04.011
关键词:
摘要: G-quadruplexes are noncannonical four-stranded DNA or RNA structures formed by guanine-rich repeating sequences. Guanine nucleotides can hydrogen bond to form a planar tetrad structure. Such tetrads stack quadruplexes of various molecularities with variety types single-stranded loops joining the tetrads. High-resolution may be obtained X-ray crystallography NMR spectroscopy for short (≈25 nt) sequences but these methods have yet succeed in characterizing higher order quadruplex longer An integrated computational and experimental approach was implemented our laboratory obtain structural models that might telomeric promoter In approach, atomic-level built using folding principles gleaned from available high-resolution then optimized molecular dynamics. The program HYDROPRO is used construct bead predict experimentally testable hydrodynamic properties. Models validated comparison properties measured values analytical ultracentrifugation other biophysical tools. This chapter describes practical procedures.
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