Anti-D in Rh(D)-Negative Pregnant Women: Are At-Risk Pregnancies and Deliveries Receiving Appropriate Prophylaxis?

摘要: Abstract Objective Although anti-D prophylaxis has greatly reduced the rate of Rh-immunization, there remain women who sensitize during or after pregnancy because inadequate prophylaxis. The purpose this study was to compare adherence recommendations for antenatal and postnatal immunoglobulin administration. Methods We conducted a retrospective cohort all pregnancies recorded at Royal Victoria Hospital between 2001 2006 determine rates in Rh(D)-negative women. compared our institution's physician-dependent approach protocolbased postpartum approach. Logistic regression analysis used estimate odds ratio 95% confidence intervals determinants non-adherence current Results Antenatal administration analyzed 1868 eligible Rh-negative Among these women, 85.7% received appropriate 98.5% Factors independently associated with antepartum included first visit third trimester (P Conclusion Unlike hospital-based protocol-dependent systems, systems subject errors omission. A more standardized system is needed ensure effective