Global regulation of genome duplication in eukaryotes: an overview from the epifluorescence microscope
作者： John Herrick , Aaron Bensimon
DOI: 10.1007/S00412-007-0145-1
关键词:
摘要: In eukaryotes, DNA replication is initiated along each chromosome at multiple sites called origins. Locally, origin “licensed” or specified the end of M and beginning G1 phases cell cycle. During S phase when synthesis takes place, origins are activated in stages corresponding to early late-replicating domains. The staged progressive activation reflects need maintain a strict balance between number active forks rate which proceeds. This suggests that densities (frequency initiation) fork movement (rates elongation) must be coregulated guarantee efficient complete duplication subchromosomal domain. Emerging evidence supports this proposal ATM/ATR intra-S checkpoint plays an important role coregulation initiation frequencies rates elongation. paper, we review recent results concerning mechanisms governing global regulation discuss roles these play maintaining genome stability during both normal perturbed phase.
springer.com
sci-hub.se 参考文章(126)
Daniela S. Dimitrova, David M. Gilbert, Temporally coordinated assembly and disassembly of replication factories in the absence of DNA synthesis Nature Cell Biology. ,vol. 2, pp. 686- 694 ,(2000) , 10.1038/35036309
J. Julian Blow, Peter J. Gillespie, Dennis Francis, Dean A. Jackson, Replication origins in Xenopus egg extract Are 5-15 kilobases apart and are activated in clusters that fire at different times. Journal of Cell Biology. ,vol. 152, pp. 15- 25 ,(2001) , 10.1083/JCB.152.1.15
Michelle M Le Beau, Feyruz V Rassool, Mary E Neilly, Rafael Espinosa III, Thomas W Glover, David I Smith, Timothy W McKeithan, Replication of a common fragile site, FRA3B, occurs late in S phase and is delayed further upon induction: implications for the mechanism of fragile site induction Human Molecular Genetics. ,vol. 7, pp. 755- 761 ,(1998) , 10.1093/HMG/7.4.755
Ivan Mamely, Marcel ATM van Vugt, Veronique AJ Smits, Jennifer I. Semple, Bennie Lemmens, Anastassis Perrakis, René H. Medema, Raimundo Freire, Polo-like Kinase-1 Controls Proteasome-Dependent Degradation of Claspin during Checkpoint Recovery Current Biology. ,vol. 16, pp. 1950- 1955 ,(2006) , 10.1016/J.CUB.2006.08.026
Jennifer A. Seiler, Chiara Conti, Ali Syed, Mirit I. Aladjem, Yves Pommier, The Intra-S-Phase Checkpoint Affects both DNA Replication Initiation and Elongation: Single-Cell and -DNA Fiber Analyses Molecular and Cellular Biology. ,vol. 27, pp. 5806- 5818 ,(2007) , 10.1128/MCB.02278-06
T I Kuschak, B C Kuschak, C L Taylor, J A Wright, F Wiener, S Mai, c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene Oncogene. ,vol. 21, pp. 909- 920 ,(2002) , 10.1038/SJ.ONC.1205145
Claus Storgaard Sørensen, Randi G. Syljuåsen, Jiri Lukas, Jiri Bartek, ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage. Cell Cycle. ,vol. 3, pp. 941- 945 ,(2004) , 10.4161/CC.3.7.972
MIchelle Debatisse, Eliane El Achkar, Bernard Dutrillaux, Common fragile sites nested at the interfaces of early and late-replicating chromosome bands: cis acting components of the G2/M checkpoint? Cell Cycle. ,vol. 5, pp. 578- 581 ,(2006) , 10.4161/CC.5.6.2574
Yokos Kaneko, Nobumoto Watanabe, Hirobumi Morisaki, Hidetoshi Akita, Atsushi Fujimoto, Kaoru Tominaga, Motomu Terasawa, Akira Tachibana, Kyoji Ikeda, Makoto Nakanishi, Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene. ,vol. 18, pp. 3673- 3681 ,(1999) , 10.1038/SJ.ONC.1202706
M. Masata, I. Raska, J. Malinsky, I. Votruba, D. Stanek, K. Koberna, The supply of exogenous deoxyribonucleotides accelerates the speed of the replication fork in early S-phase. Journal of Cell Science. ,vol. 114, pp. 747- 750 ,(2001)