Long-term survival and differentiation of retinal neurons derived from human embryonic stem cell lines in un-immunosuppressed mouse retina
作者： Anand Swaroop , Igor O Nasonkin , Matthew Brooks , Kye-Yoon Park , Ron McKay
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摘要: Purpose To examine the potential of NIH-maintained human embryonic stem cell (hESC) lines TE03 and UC06 to differentiate into retinal progenitor cells (hESC-RPCs) using noggin/Dkk-1/IGF-1/FGF9 protocol. An additional goal is in vivo dynamics maturation integration subretinal epiretinal (vitreous space) hESC-RPC grafts without immunosuppression.
molvis.org参考文章(78)
Lian Zhao, Wenxin Ma, Robert N. Fariss, Wai T. Wong, Minocycline Attenuates Photoreceptor Degeneration in a Mouse Model of Subretinal Hemorrhage The American Journal of Pathology. ,vol. 179, pp. 1265- 1277 ,(2011) , 10.1016/J.AJPATH.2011.05.042
Gregory M. Acland, Konrad A. Kauper, Paul F. Stabila, Rong Wen, Gustavo D. Aguirre, Alan M. Laties, Sandy D. Sherman, Brenda J. Dean, William G. Tsiaras, Veronica A. Budz, William J. Bell, Moses B. Goddard, Pam J. O’Rourke, Sue Pearce-Kelling, Weng Tao, Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 3292- 3298 ,(2002)
Constancia del Cerro, Nobutsugu Hayashi, Manuel del Cerro, Jingtai Cao, W. Richard Green, Eugene de Juan, Mark S. Humayun, Srinivas R. Sadda, Histologic correlation of human neural retinal transplantation. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 3142- 3148 ,(2000)
M Jorquera, L Q Jiang, J W Streilein, Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts. Investigative Ophthalmology & Visual Science. ,vol. 34, pp. 3347- 3354 ,(1993)
Gerald J. Chader, James Weiland, Mark S. Humayun, Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis. Progress in Brain Research. ,vol. 175, pp. 317- 332 ,(2009) , 10.1016/S0079-6123(09)17522-2
Matthew M. LaVail, Michael T. Matthes, Douglas Yasumura, Kazuhiko Unoki, Roy H. Steinberg, Cathy Lau-Villacorta, Ching-Hwa Sung, Protection of mouse photoreceptors by survival factors in retinal degenerations. Investigative Ophthalmology & Visual Science. ,vol. 39, pp. 592- 602 ,(1998)
E.L. West, R.A. Pearson, M. Tschernutter, J.C. Sowden, R.E. MacLaren, R.R. Ali, Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors. Experimental Eye Research. ,vol. 86, pp. 601- 611 ,(2008) , 10.1016/J.EXER.2008.01.004
Juliane Gust, Thomas A. Reh, Adult Donor Rod Photoreceptors Integrate into the Mature Mouse Retina Investigative Opthalmology & Visual Science. ,vol. 52, pp. 5266- 5272 ,(2011) , 10.1167/IOVS.10-6329
Anna Erlandsson, Chia-Hsun Anthony Lin, Fenggang Yu, Cindi M. Morshead, Immunosuppression promotes endogenous neural stem and progenitor cell migration and tissue regeneration after ischemic injury Experimental Neurology. ,vol. 230, pp. 48- 57 ,(2011) , 10.1016/J.EXPNEUROL.2010.05.018
K. Sakagami, L. Gan, X.-J. Yang, Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina. The Journal of Neuroscience. ,vol. 29, pp. 6932- 6944 ,(2009) , 10.1523/JNEUROSCI.0289-09.2009