摘要: The tumor suppressor p53 (TP53) is the most frequently mutated human gene. Mutations in TP53 not only disrupt its tumor suppressor function, but also endow oncogenic gain-of-function (GOF) activities in a manner independent of wild-type TP53 (wtp53). Mutant TP53 (mutp53) GOF is mainly mediated by its binding with other tumor suppressive or oncogenic proteins. Increasing evidence indicates that stabilization of mutp53 is crucial for its GOF activity. However, little is known about factors that alter mutp53 stability and its oncogenic …
mdpi.com
sci-hub.se 参考文章(165)
Jian Yuan, Kuntian Luo, Lizhi Zhang, John C. Cheville, Zhenkun Lou, USP10 Regulates p53 Localization and Stability by Deubiquitinating p53 Cell. ,vol. 140, pp. 384- 396 ,(2010) , 10.1016/J.CELL.2009.12.032
Zheng Yun Zhang, Doopyo Hong, Seung Hoon Nam, Jong Man Kim, Yong Han Paik, Jae Won Joh, Choon Hyuck David Kwon, Jae Berm Park, Gyu-Seong Choi, Kyu Yun Jang, Cheol Keun Park, Sung Joo Kim, SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma Journal of Hepatology. ,vol. 62, pp. 121- 130 ,(2015) , 10.1016/J.JHEP.2014.08.007
F. M. Boeckler, A. C. Joerger, G. Jaggi, T. J. Rutherford, D. B. Veprintsev, A. R. Fersht, Targeted rescue of a destabilized mutant of p53 by an in silico screened drug Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 10360- 10365 ,(2008) , 10.1073/PNAS.0805326105
Damian B. S. Yap, Jung-Kuang Hsieh, Shan Zhong, Vicky Heath, Barry Gusterson, Tim Crook, Xin Lu, Ser392 Phosphorylation Regulates the Oncogenic Function of Mutant p53 Cancer Research. ,vol. 64, pp. 4749- 4754 ,(2004) , 10.1158/0008-5472.CAN-1305-2
Sue Haupt, Silvia di Agostino, Inbal Mizrahi, Osnat Alsheich-Bartok, Mathijs Voorhoeve, Alex Damalas, Giovanni Blandino, Ygal Haupt, Promyelocytic Leukemia Protein is Required for Gain of Function by Mutant p53 Cancer Research. ,vol. 69, pp. 4818- 4826 ,(2009) , 10.1158/0008-5472.CAN-08-4010
Elsa R. Flores, Kenneth Y. Tsai, Denise Crowley, Shomit Sengupta, Annie Yang, Frank McKeon, Tyler Jacks, p63 and p73 are required for p53-dependent apoptosis in response to DNA damage Nature. ,vol. 416, pp. 560- 564 ,(2002) , 10.1038/416560A
Xuetian Yue, Yuhan Zhao, Juan Liu, Cen Zhang, Haiyang Yu, Jiabei Wang, Tongsen Zheng, Lianxin Liu, Jun Li, Zhaohui Feng, Wenwei Hu, BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function eLife. ,vol. 4, ,(2015) , 10.7554/ELIFE.08401
Stephanie Geisler, Anne-Lise Børresen-Dale, Hilde Johnsen, Turid Aas, Jurgen Geisler, Lars Andreas Akslen, Gun Anker, Per Eystein Lønning, None, TP53 gene mutations predict the response to neoadjuvant treatment with 5-fluorouracil and mitomycin in locally advanced breast cancer. Clinical Cancer Research. ,vol. 9, pp. 5582- 5588 ,(2003)
Katja Schuster, Liying Fan, Linda C. Harris, MDM2 splice variants predominantly localize to the nucleoplasm mediated by a COOH-terminal nuclear localization signal. Molecular Cancer Research. ,vol. 5, pp. 403- 412 ,(2007) , 10.1158/1541-7786.MCR-06-0146
Atsushi Kurabayashi, Mutsuo Furihata, Manabu Matsumoto, Naotami Terao, Taro Shuin, Morimasa Kuwahara, Tamotsu Takeuchi, Yuji Ohtsuki, p53 mutation arising in Arg72 allele in the tumorigenesis and development of carcinoma of the urinary tract. Clinical Cancer Research. ,vol. 8, pp. 1192- 1195 ,(2002)