Cyclic ether compounds as sodium channel modulators
作者： Kohji Fukatsu , Shigenori Ohkawa , Tadatoshi Hashimoto
DOI:
关键词:
摘要: A compound of formula (I) wherein R?1 and R2? each represents hydrogen, lower alkyl which may be substituted or acyl; R?3, R4 R5? alkoxy R?4 taken together represent a 5- 6-membered carbocyclic group; R6 alkyl; Ar an aromatic group substituted; ring to 8-membered nitrogen-containing heterocyclic X lowe alkylene Y carbon nitrogen; Za CH?2?, COCH2, OCH2, SCH2, NHCH2, etc.; Zb bond divalent aliphatic hydrocarbon contain O, N S; m integer 1 3, salt thereof is useful for pharmaceutical composition modulating sodium channel.
google.com.tr 参考文章(4)
Karnail S. Atwal, Gary J. Grover, Syed Z. Ahmed, Francis N. Ferrara, Timothy W. Harper, Kyoung S. Kim, Paul G. Sleph, Steven Dzwonczyk, Anita D. Russell, Cardioselective anti-ischemic ATP-sensitive potassium channel openers. Journal of Medicinal Chemistry. ,vol. 36, pp. 3971- 3974 ,(1993) , 10.1021/JM00076A027
Shigenori Ohkawa, Kohji Fukatsu, Shokyo Miki, Tadatoshi Hashimoto, Junko Sakamoto, Takayuki Doi, Yasuo Nagai, Tetsuya Aono, 5-Aminocoumarans : Dual inhibitors of lipid peroxidation and dopamine release with protective effects against central nervous system trauma and ischemia Journal of Medicinal Chemistry. ,vol. 40, pp. 559- 573 ,(1997) , 10.1021/JM960411J
Takayuki Doi, Tetsuya Aono, Shigenori Ohkawa, Aminocoumaran derivatives, their production and use ,(1991)
Shokyo Miki, Shigenori Ohkawa, Crystalline salts of optically active aminocoumaran derivatives, their production and use ,(1993)