Identification of genes associated with histologic tumor grade of esophageal squamous cell carcinoma.
作者： Jiaqiang Xing , Cuicui Liu
关键词:
摘要: The present study aimed to identify the genes associated with histologic tumor grade of patients esophageal squamous cell carcinoma (ESCC) and provide valuable information for identification potential diagnostic biomarkers in ESCC. Tumor samples ESCC retrieved from Cancer Genome Atlas were divided into Grade 1 (well-differentiated; G1), 2 (moderately-differentiated; G2) 3 (poorly-differentiated; G3) groups accordance clinical record patients. identified. signaling pathways identified enriched Kyoto Encyclopedia Genes Genomes (KEGG). value candidate was assessed by receiver operating characteristic analysis. We used GSE23400 dataset generated Gene Expression Omnibus examine expression levels tissues compared matched mucosa tissues. In total, 440 positively correlated 882 negatively There 310 differentially expressed (DEGs) between G1 G2, 184 DEGs G2 G3, 710 G3. 1322 that significantly cancer phospholipase D pathway. Cyclin-dependent kinase inhibitor 1A, golgin A7 family member B transforming growth factor B1-induced anti-apoptotic (TIAF1) had discriminating those TIAF1 down-regulated results comprise useful groundwork respect determining tumorigenesis mechanism discovering
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