Endothelial Progenitor Cells from Cord Blood: Magic Bullets Against Ischemia?

作者: Maurizio Pesce , Giulio Pompilio , Maurizio C. Capogrossi

DOI: 10.1007/978-1-84882-718-9_21

关键词:

摘要: The use of Endothelial Progenitor Cells (EPCs) in therapy is nowadays considered a feasible option to enhance neo-vascularization the ischemic heart and lower limbs. Although autologous EPC sources such as bone marrow (BM) peripheral blood (PB) have been already validated for their promote angiogenesis, heterologous cord (CB) not yet approved patients, due risk immune response induction. Studies animal models ischemia shown, however, that protocols pharmacologically suppress allow potentially successful cord-blood-derived CD34+ cells.

参考文章(82)
Amnon Peled, Orit Kollet, Tanya Ponomaryov, Isabelle Petit, Suzanna Franitza, Valentin Grabovsky, Michal Magid Slav, Arnon Nagler, Ofer Lider, Ronen Alon, Dov Zipori, Tsvee Lapidot, The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34(+) cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice. Blood. ,vol. 95, pp. 3289- 3296 ,(2000) , 10.1182/BLOOD.V95.11.3289
Qun Shi, Shahin Rafii, Moses Hong-De Wu, Errol S. Wijelath, Cong Yu, Atsushi Ishida, Yuji Fujita, Sudesh Kothari, Robert Mohle, Lester R. Sauvage, Malcom A.S. Moore, Rainer F. Storb, William P. Hammond, Evidence for Circulating Bone Marrow-Derived Endothelial Cells Blood. ,vol. 92, pp. 362- 367 ,(1998) , 10.1182/BLOOD.V92.2.362
Toshiharu Eto, Hiroshi Takahashi, Enhanced inhibition of hepatitis B virus production by asialoglycoprotein receptor-directed interferon Nature Medicine. ,vol. 5, pp. 577- 581 ,(1999) , 10.1038/8462
Peter Carmeliet, Yuval Dor, Jean-Marc Herbert, Dai Fukumura, Koen Brusselmans, Mieke Dewerchin, Michal Neeman, Françoise Bono, Rinat Abramovitch, Patrick Maxwell, Cameron J. Koch, Peter Ratcliffe, Lieve Moons, Rakesh K. Jain, Désiré Collen, Eli Keshet, Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. ,vol. 394, pp. 485- 490 ,(1998) , 10.1038/28867
Tomono Takahashi, Christoph Kalka, Haruchika Masuda, Donghui Chen, Marcy Silver, Marianne Kearney, Meredith Magner, Jeffrey M. Isner, Takayuki Asahara, Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nature Medicine. ,vol. 5, pp. 434- 438 ,(1999) , 10.1038/7434
Aaron Liew, Frank Barry, Timothy O'Brien, Endothelial progenitor cells: diagnostic and therapeutic considerations BioEssays. ,vol. 28, pp. 261- 270 ,(2006) , 10.1002/BIES.20372
Jean-Jacques Lataillade, Denis Clay, Philippe Bourin, Françis Hérodin, Catherine Dupuy, Claude Jasmin, Marie-Caroline Le Bousse-Kerdilès, Stromal cell–derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in CD34+ cells: evidence for an autocrine/paracrine mechanism Blood. ,vol. 99, pp. 1117- 1129 ,(2002) , 10.1182/BLOOD.V99.4.1117
Juan M. Melero-Martin, Zia A. Khan, Arnaud Picard, Xiao Wu, Sailaja Paruchuri, Joyce Bischoff, In vivo vasculogenic potential of human blood-derived endothelial progenitor cells Blood. ,vol. 109, pp. 4761- 4768 ,(2007) , 10.1182/BLOOD-2006-12-062471
C URBICH, A AICHER, C HEESCHEN, E DERNBACH, W HOFMANN, A ZEIHER, S DIMMELER, Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells Journal of Molecular and Cellular Cardiology. ,vol. 39, pp. 733- 742 ,(2005) , 10.1016/J.YJMCC.2005.07.003
Jalees Rehman, Jingling Li, Christie M. Orschell, Keith L. March, Peripheral Blood “Endothelial Progenitor Cells” Are Derived From Monocyte/Macrophages and Secrete Angiogenic Growth Factors Circulation. ,vol. 107, pp. 1164- 1169 ,(2003) , 10.1161/01.CIR.0000058702.69484.A0