Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
作者： Yingchang Lu , Sun-Seog Kweon , Chizu Tanikawa , Wei-Hua Jia , Yong-Bing Xiang
DOI: 10.1053/J.GASTRO.2018.11.066
关键词:
摘要: Background & Aims Genome-wide association studies (GWASs) have associated approximately 50 loci with risk of colorectal cancer (CRC)—nearly one third these were initially CRC in conducted East Asian populations. We a GWAS Asians to identify and evaluate the generalizability findings from GWASs European populations Methods analyzed genetic data 22,775 patients (cases) 47,731 individuals without (controls) 14 Asia Colorectal Cancer Consortium. First, we performed meta-analysis 7 (10,625 cases 34,595 controls) identified 46,554 promising variants for replication by adding them Multi-Ethnic Global Array (MEGA) genotype analysis 6445 7175 controls. These analyzed, along an additional 5705 5961 controls genotyped using OncoArray. also obtained 57,976 67,242 descent. Variants at functionally annotated evaluated correlation gene expression levels. Results A meta-analyses all samples people descent 13 1 new variant known locus (10q24.2) genome-wide significance level P Conclusions showed that most previously Asians. Furthermore, significantly Many contained genes regulate immune response, Wnt signaling β-catenin, prostaglandin E2 catabolism, cell pluripotency proliferation. Further analyses their is warranted, particularly 8 which lead not replicated persons
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