Transferrin and Iron in Normal, Alzheimer's Disease, and Parkinson's Disease Brain Regions

摘要: Oxidant-mediated damage is suspected to be involved in the pathogenesis of several neurodegenerative disorders. Iron promotes conversion hydrogen peroxide hydroxyl radical and, thus, may contribute oxidant stress. We measured iron and its transport protein transferrin caudate, putamen, globus pallidus, substantia nigra, frontal cortex subjects with Alzheimer's disease (n = 14) Parkinson's 14), younger adult 8) elderly normal controls. Although there were no differences between control groups regard concentrations transferrin, was significantly increased (p < 0.05) pallidus cortex, compared The transferrin/iron ratio, a measure mobilization capacity, decreased caudate both Regional generally more highly correlated (Pearson's correlation coefficient) controls than disease. altered relationship provides further evidence that disturbance metabolism