想像と創造 : 1-ヒドロキシインドール化学と夢への挑戦

摘要: We have had five dreams to challenge through our life. To meet end, we needed imaginary compounds, 1-hydroxytryptophans. This review describes how conceived the 1-hydroxyindole hypothesis, created a general synthetic method for 1-hydroxyindoles after 20 years' research, and developed chemistry of 1-hydroxytryptophans with full new findings discoveries. During period, defined "the efficient synthesis" ideal consisting originality rate (OR), intellectual property factor (IPF), application potential (APF). For evaluating efficiency these indexes are more effective than both citation index impact factor. Taking advantage chemistry, achieved three "ideal syntheses" approximately high OR, IPF, APF values. The methods employ only conventional reagents reaction conditions without using any protecting groups. These made possible produce such properties as leads an alpha(2)-blocker, inhibitor platelet aggregation, anti-osteoporosis agent, promising medicine combating desertification, changing Gobi desert tract green plants. would be suitable realizing dreams. Chemical conversion enmein gibberellin A(15), four-step total synthesis optically active ergot alkaloids, various reactions 4-substituted indoles also involved.