Complete form pachydermoperiostosis in Tunisia – A case series and literature review

摘要: Abstract Introduction Pachydermoperiostosis (PDP) or hypertrophic osteoarthropathy (HOA) is a rare disease that has genetic predisposition and defined clinical features. Aim of the work To study analyse features Tunisian PDP patients review literature. Patients methods The cases attending Rheumatology Department University Hospital Farhat Hached Sousse in Tunisia were retrospectively studied over period 17 years (2000–2017). Secondary causes excluded. Results had primary complete form included 6 men at frequency 0.03% (6/20,000) total number rheumatic diseases rheumatology clinic. mean age was 27 ± 12.3 years [18–46 years]. Five arthralgia one polyarthritis. Thickening skin head distal extremities (pachyderma) deep folds furrows forehead observed all cases. Digital clubbing fingers toes spade-like enlargement hands feet noted 5 Hyperhidrosis 4 seborrhea 2. Elevated acute phase reactants found Hypergammaglobulinemia present case. Periostosis long bones Treatment consisted analgesics cases, non-steroidal anti-inflammatory drugs 2 tamoxifen Conclusions Complete rarely among Tunisia. A multicenter larger longitudinal recommended.