The cytokine-HPA axis feed-back circuit.

摘要: Due to their anti-inflammatory effects and capacity affect the synthesis of most cytokines Th1/Th2 balance, endogenous glucocorticoids contribute control basal operation immune cells. Immune processes result in production cytokines, such as IL-1, IL-2, IL-6, IL-11, IL-12, TNF-alpha, INF-gamma, which can activate HPA axis. In turn, resulting increase glucocorticoid blood levels cell activity directly or by controlling suggesting existence an immunoregulatory cytokine-HPA axis circuit. There is evidence that this circuit plays a relevant role excessive inflammatory reactions non-specific expansion cells with no low affinity for antigen triggers response.