Poor response at restaging MRI and high incomplete resection rates of locally advanced mucinous rectal cancer after chemoradiation therapy.

摘要: AIM Mucinous carcinoma is a histological subtype of rectal cancer and has been associated with poor response to neoadjuvant chemoradiotherapy (CRT). The primary aim this study was analyze the on MRI mucinous locally-advanced (LARC) after CRT compared regular adenocarcinoma. METHOD Patients LARC (defined as cT4 and/or cN2), who underwent followed by restaging surgery in 2 tertiary referral hospitals were retrospectively included study. Pre- post-treatment reviewed an experienced abdominal radiologist. RESULTS A total 102 patients, which 29 diagnosed carcinoma, for analysis. At MRI, adenocarcinoma patients demonstrated significantly less clinical involvement mesorectal fascia (MRF) (37% vs 62%, p=0.003) while not (86% 97%, p=0.16). Significant downstaging (p=0.01) seen no (p = 0.89) seen. Pathology revealed higher rates involved circumferential resection margin (CRM) versus (27.6% 1.4%; p < 0.001). After multivariate regression analysis, remained independent prognostic factor local recurrence (HR 3.6; CI 1.1-12.4), although differences overall or disease-free survival observed. CONCLUSION at CRT, leading relatively CRMs pathology. In cohort, seems be increased risk recurrence, without effect survival.