The molecular choreography of protein synthesis: translational control, regulation, and pathways.

摘要: Translation of proteins by the ribosome regulates gene expression, with recent results underscoring importance translational control. Misregulation translation underlies many diseases, including cancer and genetic diseases. Decades biochemical structural studies have delineated mechanistic details in prokaryotic translation, sketched outlines eukaryotic translation. However, may not proceed linearly through a single pathway, but likely involves multiple pathways branchpoints. The stochastic nature biological processes would allow different to occur during that are biased interaction other factors, steps kinetically controlled. These branchpoints potential regulatory nexus, allowing expression be tuned at level. As research focus shifts toward certain themes will echoed from on This review provides general overview dynamic data related particular findings single-molecule methods, complemented biochemical, kinetic, findings. We underscore viewing process viewpoints regulation, control, heterogeneous pathways.