Study of EGFR mutations in head and neck squamous cell carcinomas.

摘要: Introduction Squamous carcinoma is the commonest malignancy of head and neck region. It associated with high morbidity mortality. Epidermal growth factor receptor (EGFR) regulates downstream signaling pathways through its tyrosine kinase (TK) domains that play a role in cell proliferation survival. EGFR mutations have been found to occur between exons 18 21 on chromosome 7. Limited studies are available EGFR-TK squamous (HNSCC) globally. This study explores 30 HNSCC cases presenting tertiary care hospital over period two years. Material methods Fresh tumor tissue was collected from resection specimens primary HNSCC. Cases pre-operative therapy were not included. Parameters form patients' age, gender, smoking/tobacco intake, site lesion recorded. Tumor parameters after histopathological examination recorded TNM stage, grade. DNA extracted fresh all cases. Mutation Analysis Kit assay used detect gene. PCR run results analyzed. Results Mutations 6.7%of patients. There no significant association studied parameters. Conclusion present subset patients Patients having these may benefit targeted inhibitors.