An Iridium-Catalyzed Reductive Approach to Nitrones from N-Hydroxyamides

摘要: An Ir-catalyzed reductive formation of functionalized nitrones from N-hydroxyamides was reported. The reaction took place through two types iridium-catalyzed reactions including dehydrosilylation and hydrosilylation. method showed high chemoselectivity in the presence sensitive functional groups, such as methyl esters, successfully applied to synthesis cyclic macrocyclic nitrones, which are known be challenging compounds access by conventional methods. 1H NMR studies strongly supported generation an N-siloxyamide N,O-acetal actual intermediates.