Guidelines for accurate EC50/IC50 estimation

作者: J. L. Sebaugh

DOI: 10.1002/PST.426

关键词:

摘要: … 4-parameter logistic model and is the concentration corresponding to a response midway between the estimates … be more than 5% error in the estimate of the 50% control mean should …

参考文章(5)
A DeLean, P J Munson, D Rodbard, Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves. American Journal of Physiology-endocrinology and Metabolism. ,vol. 235, ,(1978) , 10.1152/AJPENDO.1978.235.2.E97
David John Finney, Statistical method in biological assay. Statistical method in biological assay.. ,(1952)
Gang Li, Dibyen Majumdar, D-optimal designs for logistic models with three and four parameters Journal of Statistical Planning and Inference. ,vol. 138, pp. 1950- 1959 ,(2008) , 10.1016/J.JSPI.2007.07.010
J. L. Sebaugh, P. D. McCray, Defining the linear portion of a sigmoid‐shaped curve: bend points Pharmaceutical Statistics. ,vol. 2, pp. 167- 174 ,(2003) , 10.1002/PST.62
Leonid A. Khinkis, Laurence Levasseur, Hélène Faessel, William R. Greco, Optimal design for estimating parameters of the 4-parameter hill model. Nonlinearity in Biology, Toxicology, and Medicine. ,vol. 1, pp. 363- 377 ,(2003) , 10.1080/15401420390249925