Human Brain Myelination Trajectories Across the Life Span: Implications for CNS Function and Dysfunction

摘要: Publisher Summary In this chapter, changes in human brain myelination are discussed the context of development and degeneration over life span with a focus on implications for function as well dysfunction. Postmortem data vivo imaging evidence suggest that process myelin production subsequent breakdown may be directly relevant to deepening understanding biology brain. The inverted-U-shaped trajectories occur help explain patterns cognitive, behavioral, emotional define our everyday lives from impulsiveness youth wisdom older ages. More importantly many unique but highly prevalent devastating diseases plague species at various phases life. model posits uniquely pervasive protracted renders continuum vulnerability culminates later-developing oligodendrocytes. Genetic and/or environmental effects impact will manifest risk factors (or protective factors) developmental disorders such autism schizophrenia, aging-related AD Parkinson disease.