Cytotoxicity and antiangiogenic effects of Rhus coriaria, Pistacia vera and Pistacia khinjuk oleoresin methanol extracts

摘要: Angiogenesis, formation of new blood vessels, play an important role in some diseases such as cancer and its metastasis. Using angiogenesis inhibitors, therefore, is one the ways for treatment prevention Medicinal plants have been shown to a major variety cancers. In this direction, cytotoxic angiogenic effects oleo gum resin extracts Rhus coriaria, Pistacia vera khinjuk from Anacardiaceae family were studied. For IC50 values, plant evaluated at different concentrations (1, 10, 20, 40, 80,100 μg/ml) against human umbilical vein endothelial normal cell (HUVEC) Y79 lines using 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. vitro tube on matrigel base was used evaluate presence increasing (50, 100, 250 extracts. Vascular endothelium growth factor stimulator. Gas chromatography results showed that α-pinene β-pinene essential oils constituents all According MTT assay results, R. coriaria extract more than those P. (IC50, 9.1 ± 1.6 vs 9.8 2.1 12.0 1.9, respectively; P<0.05). Cytotoxic line significantly higher HUVEC (P<0.05). Tube also inhibited other tested It could be concluded possess effect antiangiogenesis cells anticancer natural product has good potential future studies.