The Immune Response Modifier and Toll-Like Receptor 7 Agonist S-27609 Selectively Induces IL-12 and TNF-α Production in CD11c+CD11b+CD8− Dendritic Cells
作者： Christie L. Doxsee , Tony R. Riter , Michael J. Reiter , Shelia J. Gibson , John P. Vasilakos
DOI: 10.4049/JIMMUNOL.171.3.1156
关键词:
摘要: IL-12 and TNF-alpha production by dendritic cells (DCs) is a critical step in the initiation of local inflammation adaptive immune responses. We show this study that small molecule response modifier Toll-like receptor 7 (TLR7) agonist induces from murine CD11c(+)CD11b(+)CD8(-) DCs, subset not previously known for activity. Stimulation these DCs through TLR7 vivo significant cytokine even 12 h after initial stimulation, as well migration DC into T cell zones lymphoid tissue. In contrast, stimulation TLR4 TLR9 induced predominantly CD8(+) consistent with published data. All TLR stimuli increase surface expression activation markers B7-1, B7-2, class II both CD8(-) demonstrating do respond to TLR7-mediated stimuli. To date only induce preferential DCs. Given efficacy agonists antiviral agents, data collectively indicate most likely plays role generation
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