Quantitative histologic analyses of articular cartilage and subchondral bone from osteoarthritic and normal human hips.

摘要: Twelve femoral heads (two normal, four after fracture and six osteoarthritic) were obtained at surgery or autopsy. Circumferential slices five separate areas analyzed in each for ash content; histological-histochemical grading of the severity cartilage changes; quantitative morphometric analyses to establish percentage trabecular area, osteoblastic area osteoclastic area. Analyses performed compare weight-bearing non-weight-bearing determine correlations between bony cartilaginous alterations. The data showed wide variations all parameters osteoarthritic specimens but consistently more marked changes areas. Bone structures metabolic distinctly increased osteoarthritics, differing significantly from both normal control groups. change correlated directly with lesions, as d...