Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence

摘要: BACKGROUND: Earlier studies have suggested that infant feeding may program long-term changes in cholesterol metabolism. OBJECTIVE: We aimed to examine whether breastfeeding is associated with lower blood concentrations adulthood. DESIGN: The study consisted of a systematic review published observational relating initial status adulthood (ie, aged >16 y). Data were available from 17 (17 498 subjects; 12 890 breastfed, 4608 formula-fed). Mean differences total (breastfed minus formula-fed) pooled by using fixed-effect models. Effects adjustment (for age at outcome, socioeconomic position, body mass index, and smoking status) exclusion (of nonexclusive breast feeders) examined. RESULTS: was (P = 0.037) among those ever breastfed than fed formula milk (mean difference: -0.04 mmol/L; 95% CI: -0.08, 0.00 mmol/L). difference between groups larger 0.005) more consistent 7 analyzed "exclusive" patterns (-0.15 -0.23, -0.06 mmol/L) 10 (-0.01 -0.06, 0.03 Adjustment for potential confounders including adult life had minimal effect on these estimates. CONCLUSIONS: Initial (particularly when exclusive) be later life. Moves reduce the content feeds below should treated caution.