Adrenocortical function in patients with macrometastases of the adrenal gland.
作者： A Lutz , M Stojkovic , M Schmidt , W Arlt , B Allolio
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摘要: Objective: Metastases of the adrenal gland are a frequent finding in patients with malignant tumors like bronchogenic carcinoma or breast cancer. Only limited and conflicting data on adrenocortical function these available. Design: Cross-sectional study. Methods: We investigated impact macrometastases series 28 tumor using ACTH1‐24 stimulation test dexamethasone suppression test. Seven normal controls (Con), eleven without metastases (No Met), eight unilateral (Uni Met) nine bilateral (Bil were investigated. Results: The prevalence insufficiency was low our study population, only two having subclinical insufficiency. In remaining uni- metastases, baseline stimulated cortisol concentrations higher than cancer (baseline (in nmol/l): Con: 307633.2 vs Uni Met: 440 6 53.5, Bil 637.6 92.1, P 0.04 by ANOVA; 60 min after :C on: 794.66 41.2 990.8 92.9, 1151.4 155.5, 0.03 ANOVA). Simultaneously, serum aldosterone significantly blunted groups. Conclusions: Adrenal is infrequent develops metastases. However, majority have activation hypothalamic‐pituitary‐adrenal axis despite strongly elevated concentrations.
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sci-hub.se 参考文章(32)
Pickren Jw, Blumenson Le, Elias Eg, Cedermark Bj, Holyoke De, Ths significance of metastases to the adrenal glands in adenocarcinoma of the colon and rectum. Surgery gynecology & obstetrics. ,vol. 144, pp. 537- ,(1977)
H Takatera, H Itatani, M Utsunomiya, T Tsujimura, H Itoh, Bilateral primary non-Hodgkin's lymphoma of the adrenal glands with adrenal insufficiency: a case report. Hinyokika kiyo. Acta urologica Japonica. ,vol. 38, pp. 311- 314 ,(1992)
David Huminer, Moshe Garty, Mordechai Lapidot, Sara Leiba, Haim Borohov, Joseph B. Rosenfeld, Lymphoma presenting with adrenal insufficiency: Adrenal enlargement on computed tomographic scanning as a clue to diagnosis The American Journal of Medicine. ,vol. 84, pp. 169- 172 ,(1988) , 10.1016/0002-9343(88)90029-0
Steven M. Dubinett, Koichi Uyemura, Sherven Sharma, Robert Modlin, Min Huang, Jenny T. Mao, Jianyi Wang, Paul Lee, Horst Meissner, Jerome Wollman, Human non-small cell lung cancer cells express a type 2 cytokine pattern Cancer Research. ,vol. 55, pp. 3847- 3853 ,(1995)
David J. Seidenwurm, Edward B. Elmer, Lee M. Kaplan, Ellen K. Williams, Deborah G. Morris, Andrew R. Hoffman, Metastases to the adrenal glands and the development of Addison's disease Cancer. ,vol. 54, pp. 552- 557 ,(1984) , 10.1002/1097-0142(19840801)54:3<552::AID-CNCR2820540328>3.0.CO;2-R
M Reincke, J Nieke, G P Krestin, W Saeger, B Allolio, W Winkelmann, Preclinical Cushing's syndrome in adrenal "incidentalomas": comparison with adrenal Cushing's syndrome. The Journal of Clinical Endocrinology and Metabolism. ,vol. 75, pp. 826- 832 ,(1992) , 10.1210/JCEM.75.3.1517373
Gerard A. Silvestri, James E. Lenz, Susan N. Harper, Richard A. Morse, Gene L. Colice, The Relationship of Clinical Findings to CT Scan Evidence of Adrenal Gland Metastases in the Staging of Bronchogenic Carcinoma Chest. ,vol. 102, pp. 1748- 1751 ,(1992) , 10.1378/CHEST.102.6.1748
R Sapolsky, C Rivier, G Yamamoto, P Plotsky, W Vale, Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science. ,vol. 238, pp. 522- 524 ,(1987) , 10.1126/SCIENCE.2821621
Leslie R. Sheeler, James H. Myers, John J. Eversman, Harris C. Taylor, Adrenal insufficiency secondary to carcinoma metastatic to the adrenal gland Cancer. ,vol. 52, pp. 1312- 1316 ,(1983) , 10.1002/1097-0142(19831001)52:7<1312::AID-CNCR2820520730>3.0.CO;2-O
Erick Gamelin, Véronique Beldent, Marie-Christine Rousselet, Denise Rieux, Vincent Rohmer, Norbert Ifrah, Marc Boasson, Jean-Claude Bigorgne, Non-Hodgkin's lymphoma presenting with primary adrenal insufficiency. A disease with an underestimated frequency? Cancer. ,vol. 69, pp. 2333- 2336 ,(1992) , 10.1002/1097-0142(19920501)69:9<2333::AID-CNCR2820690922>3.0.CO;2-Z