Absence of carcinogenicity of 1-nitropyrene, correction of previous results, and new demonstration of carcinogenicity of 1,6-dinitropyrene in rats.

摘要: 1-Nitropyrene (1-NP), 1,6-dinitropyrene (1,6-DNP) and 1,8-dinitropyrene (1,8-DNP), which are potent mutagenic components of diesel exhaust air pollutants, were injected subcutaneously into the back F344 rats. No tumor was induced by experimental day 650 in rats treated with 40 or 4 mg 1-NP. On other hand, 1,6-DNP at a total dose demonstrated to induce sarcomas injection site all 10 1,8-DNP doses 0.4 0.04 also 9 out rats, respectively, 320. Our previous finding that 1-NP carcinogenic possibly due contamination preparation dinitropyrenes.