The American Cancer Society Cancer Prevention Study II Nutrition Cohort

摘要: BACKGROUND Large-scale, prospective cohort studies have played a critical role in discovering factors that contribute to variability cancer risk human populations. Epidemiologists and volunteers at the American Cancer Society (ACS) were among first establish such cohorts, beginning early 1950s continuing through present, these ACS cohorts made landmark contributions many areas of epidemiologic research. METHODS AND RESULTS The Prevention Study II Nutrition Cohort was established 1992 designed investigate relation between diet other lifestyle exposures cancer, mortality, survival. The includes over 84,000 men 97,000 women who completed mailed questionnaire 1992. New questionnaires are sent surviving members every year update exposure information ascertain new occurrences cancer; 90% response rate achieved for follow-up 1997 1999. Reported cancers verified medical records, registry linkage, or death certificates. is followed actively all cases incident causes death. Through collaborative effort national division staff, volunteers, College Surgeons, blood samples collected from subgroup 40,000 storage central repository future investigation dietary, hormonal, genetic, risk. Collection DNA buccal cells an additional 50,000 underway currently will be 2002. CONCLUSIONS This both promises particularly valuable study occurrence, survival as they relate obesity weight change, physical activity various points life, vitamin supplement use, exogenous hormone medications (such aspirin nonsteroidal anti- inflammatory drugs) screening modalities. 2002;94:2490–2501. © 2002 Society. DOI 10.1002/cncr.101970