Coronary heart disease: genetic aspects.

摘要: Morbidity and mortality differences between populations, ethnic groups individuals are not satisfactorily explained by the variation of risk factors. Differences in genetic susceptibility might be responsible for a part unexplained coronary heart disease (CHD) rates. Genetic factors also significant determining level individuals. Ample evidence links to levels serum cholesterol, blood pressure diabetes. Marked sex CHD indicate role heredity development disease. The male:female ratio varies widely different countries, as well groups. These variations difficult explain environmental behavioral males females alone. degree atherosclerosis varies, depending on anatomic location atherosclerosis. Inherited disorders metabolism variability patterns provide additional indications genetics. data accumulated Israeli Ischemic Heart Disease Study over 15 years reveal an coupled with remarkably larger Patterns incidence assessed national study histologic findings arteries infants from compatible hypothesis that early structural changes partly determine latter In conclusion, our studies review epidemiologic investigations genetics degree, time course severity atherosclerotic process occurrence symptomatic CHD. This important component is relevant preventive strategies offered tools reducing burden Research into determinants both or clinical manifestation individual response measures should encouraged.