Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice.
作者： Eugenie Dubnau , John Chan , Catherine Raynaud , Vellore P. Mohan , Marie-Antoinette Lanéelle
DOI: 10.1046/J.1365-2958.2000.01882.X
关键词:
摘要: Members of the Mycobacterium tuberculosis group synthesize a family long-chain fatty acids, mycolic which are located in cell envelope. These include non-oxygenated α-mycolic acid and oxygenated keto- methoxymycolic acids. The function bacterial virulence, if any, these various types acids is unknown. We have constructed mutant strain M. with an inactivated hma (cmaA, mma4) gene; this no longer synthesizes has profound alterations its envelope permeability attenuated mice.
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