Prophylactic methylprednisolone to reduce inflammation and improve outcomes from one lung ventilation in children: a randomized clinical trial

摘要: Background One lung ventilation (OLV) results in inflammatory and mechanical injury, leading to intraoperative postoperative complications children. No interventions have been studied children minimize such injury. Objective We hypothesized that a single 2-mg·kg−1 dose of methylprednisolone given 45–60 min prior collapse would injury from OLV improve physiological stability. Methods Twenty-eight scheduled undergo were randomly assigned receive 2 mg·kg−1 (MP) or normal saline (placebo group) OLV. Anesthetic management was standardized, data collected for stability (bronchospasm, respiratory resistance, compliance). Plasma assayed markers related at timed intervals administration methylprednisolone. Results Three the placebo group experienced clinically significant complications. Respiratory resistance lower (P = 0.04) group. Pro-inflammatory cytokine IL-6 (P = 0.01), anti-inflammatory IL-10 higher (P = 0.001) Tryptase, measured before after OLV, (P = 0.03) while increased levels tryptase seen (did not achieve significance). There no side effects observed could be attributed this study. Conclusions Methylprednisolone as provides undergoing In addition, pro-inflammatory children's plasma.