Efficacy of Smartphone Applications for Smoking Cessation: A Randomized Clinical Trial
作者： Jonathan B. Bricker , Noreen L. Watson , Kristin E. Mull , Brianna M. Sullivan , Jaimee L. Heffner
DOI: 10.1001/JAMAINTERNMED.2020.4055
关键词:
摘要: Importance Smoking is a leading cause of premature death globally. Smartphone applications for smoking cessation are ubiquitous and address barriers to accessing traditional treatments, yet there limited evidence their efficacy. Objective To determine the efficacy smartphone application based on acceptance commitment therapy (ACT) vs National Cancer Institute US clinical practice guidelines (USCPG). Design, Setting, Participants A 2-group, stratified, double-blind, individually randomized trial was conducted from May 27, 2017, September 28, 2018, among 2415 adult cigarette smokers (n = 1214 ACT-based group n = 1201 USCPG-based group) with 3-, 6-, 12-month postrandomization follow-up. The study prespecified in protocol. Follow-up data collection started August 26, ended at last participant’s follow-up survey December 23, 2019. Data were analyzed February 25 April 3, 2020. primary analysis performed complete-case basis, intent-to-treat missing as multiple imputation sensitivity analyses. Interventions iCanQuit, an application, which taught triggers, QuitGuide, avoidance triggers. Main Outcomes Measures outcome self-reported 30-day point prevalence abstinence (PPA) 12 months after randomization. Secondary outcomes 7-day PPA randomization, prolonged abstinence, 3 6 imputed or coded smoking, all tobacco products (including e-cigarettes) Results (1700 women [70.4%]; 1666 White individuals [69.0%] 868 racial/ethnic minorities [35.9%]; mean [SD] age enrollment, 38.2 [10.9] years) 50 states. 3-month retention rate 86.7% (2093), 6-month 88.4% (2136), 87.2% (2107). For follow-up, iCanQuit participants had 1.49 times higher odds quitting compared QuitGuide (28.2% [293 1040] 21.1% [225 1067]; ratio [OR], 1.49; 95% CI, 1.22-1.83;P Conclusions Relevance This provides that, more efficacious thus can be impactful treatment option. Trial Registration ClinicalTrials.gov Identifier:NCT02724462
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