HER-2/neu (erbB-2) and the Cell Cycle

摘要: Signaling by the HER-2 proto-oncogene product results in activation of several biochemical pathways, which turn modulate expression and function cell cycle regulators. These alterations regulatory molecules may be critical for conception maintenance transformed phenotype conferred gene amplification overexpression. On other hand, blockade with a therapeutic intent will require reversal these effects on order interventions to effective. Data is presented suggest that G1 cyclin D1 cyclin-dependent kinase inhibitor p27KIP1 involved subversion G1/S traverse signaling pathways activated function.