Factors influencing the antitumorigenic properties of selenium in mice.

摘要: Sodium selenite (Na2SeO3) was administered at 2.0 micrograms selenium (Se) to Swiss ICR mice six times over a 9-day period by intraperitoneal (i.p.) injection or gastric gavage. Survival time significantly increased in Ehrlich ascites tumor (EAT)-bearing 170 and 20%, respectively, compared controls. In two separate studies, 5.0 Se as Na2SeO3 selenodiglutathione (GSSeSG) i.p. more effective inhibiting EAT propagation than either untreated (control) receiving sodium selenide, dimethyl selenide [(CH3)2Se] seleno-DL-cystine. another study, cells were preincubated with 1 3 ppm GSSeSG, Na2SeO3, (CH3)2Se, washed, reinoculated into mice. Only inoculated pretreated GSSeSG significant increase survival observed. The observed inhibition not limited ascitic tumors since growth of solid also inhibited treatment Na2SeO3. Following administration Na2(75)SeO3, the retained selenium-75 did blood, lung, kidney, liver. Supplementation torula yeast diet 2.5 EAT-bearing These data show that form mode influence antitumorigenic properties this trace element. addition, suggest some intermediate normal pathway for detoxification is probably responsible element's properties.