Die Rolle der Zytokine bei Knorpeldefekten und in der Knorpeltherapie
作者： C. Moser , A. Baltzer , J. Reinecke , P. Wehling
DOI: 10.1007/S00142-005-0312-4
关键词:
摘要: Zytokine spielen eine Schlusselrolle in der Pathogenese degenerativer aber auch inflammatorischer Gelenkerkrankungen wie Osteoarthrose (OA) und rheumatoiden Arthritis (RA). Eine besondere Rolle wird dabei dem Interleukin-1 TNF-α zugeschrieben. Bestimmte Zytokine, welche die Wirkung katabolen inhibieren, besitzen groses therapeutisches Potenzial werden durch zahlreiche klinische Studien derzeit naher untersucht. Stand Wissenschaft ist, dass proinflammatorische den Knorpelabbau stimulieren deren Blockade Knorpel schutzen kann.
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