Cataloguing the HIV type 1 human protein interaction network

摘要: Although many interactions between HIV-1 and human proteins have been reported in the scientific literature, no publicly accessible source for efficiently reviewing this information was available. Therefore, a project initiated an attempt to catalogue all published proteins. HIV-related articles PubMed were used develop database containing names, Entrez GeneIDs, RefSeq protein accession numbers of interacting Furthermore, brief descriptions interactions, identification describing keywords searching incorporated. Over 100,000 reviewed, resulting 1448 that interact with comprising 2589 unique HIV-1-to-human interactions. Preliminary analysis extracted data indicates 32% direct physical (e.g., binding) 68% indirect upregulation through activation signaling pathways). Interestingly, 37% found more than one protein. For example, mitogen-activated kinase 1 has surprising range 10 different Moreover, large regulatory Tat envelope proteins: 30% 33% total identified, respectively. The is at http://www.ncbi.nlm.nih.gov/RefSeq/HIVInteractions/ cross-linked other National Center Biotechnology Information databases programs via Gene. This represents continuously updated resource understanding replication pathogenesis assist accelerating development effective therapeutic vaccine interventions.